Dashboard Members
Herbert Weissbach , NAS

Dr. Herbert Weissbach , NAS

Distinguished Professor Emeritus
Florida Atlantic University
Discipline: Science
Contact

Profile

Herbert Weissbach, Ph.D. is currently Distinguished Professor Emeritus at Florida Atlantic University (FAU). He completed his undergraduate studies at the City College of New York in 1953. He received his Master and Ph.D. degrees from George Washington University, the first student in a formal program that his mentor at the NIH, Dr. Sidney Udenfriend had established with GWU. After doing postdoctoral research, In the laboratory of Dr. Horace Barker, at the University of California, Berkelely, , he returned to the NIH in 1959 and in 1969 left the NIH to help found the Roche Institute of Molecular Biology (RIMB). After the RIMB closed in the mid-1990’s, Dr Weissbach accepted a position at FAU and established the Center for Molecular Biology and Biotechnology (CMBB) , where he was Director until 1987. His major research achievements during the early years at the NIH include the elucidation of the biosynthesis and metabolism of serotonin and also melatonin, the latter working with Dr Julius Axelrod (Nobel Laureate). As a postdoctoral fellow he identified the first coenzyme form of vitamin B12 and later elucidated the role of vitamin B12 and folic acid in methionine synthesis and their relationship to one carbon metabolism. In the later years at the NIH he worked with Marshall Nirenberg (Nobel Laureate), the scientist who cracked the genetic code, and became involved in the early days of molecular Biology. He concentrated his efforts on how the information in the mRNA is used to make proteins. In his studies on elongation factor Tu in E. coli, he identified the first example of a GTP/GDP exchange reaction, later shown to play an important role in G protein coupled receptors. His studies at the RIMB, with Dr. Nathan Brot,on a ribosomal protein, led to the discovery of the enzyme methionine sulfoxide reductase (MSRA). This anzyme repairs oxidative damage to proteins resulting from oxidation of methionine residues to methionine sulfoxide. Upon coming to FAU, the previous studies on the MSR system led to a broader interest in the role of oxidative damage in diseases and especially in the aging process. Dr. Weissbach has been a mentor for more than a dozen Ph.D students and trained more than 60 postdoctoral fellows and research associates. Included in Dr. Weissbach’s Honors and Awards are membership in the National Academy of Sciences, Engineering and Medicine (NASEM), the American Academy of Microbiology, and the National Academy of Inventors. He is the recipient of the DHEW Superior Service Award, Pfizer Award in Enzyme Chemistry, City College of New York Townsend Harris Alumni Award , George Washington University Distinguished Alumni Award and the BioFlorida Lifetime Achievement Award. Dr. Weissbach has more than 460 peer reviewed publications and his ranking in his discipline by Research.com is 773 in the United States and 1303 in the world.